Engineering the Language of Immune Cells

Our research

Our research program integrates precision biomaterials, immune engineering, and systems biology to understand and control immune cell fate for therapeutic applications. We develop engineered biomaterial platforms that program T cells through precise chemical and physical control of ligand presentation, enabling mechanistic studies of immune synapse organization, trogocytosis, downstream signaling, and long-term cell fate decisions. Building on these insights, we engineer next-generation therapeutic T cells with enhanced persistence and functionality for cancer and immune diseases. In parallel, we develop strategies to reshape immune microenvironments through modulation of myeloid cell lineages. To uncover the principles governing durable immune responses, we combine transcriptomic profiling with computational network analysis to decode molecular programs controlling T-cell differentiation, persistence, and exhaustion.